Disorder/Effect |
Test to be Assessed* |
Clinical Scenario |
Target Population |
Intended Use |
|
Gene expression profile |
Women diagnosed with
breast cancer |
Treatment and
recurrence risk |
|
Multigene panel |
General population |
Risk prediction or nutritional/lifestyle management |
Colorectal Cancer (CRC) |
UGT1A1 |
Individuals
diagnosed
with CRC |
Treatment with irinotecan |
Lynch Syndrome/ Hereditary Nonpolyposis Colorectal Cancer (HNPCC) |
Mismatch repair gene mutations |
Individuals diagnosed with CRC and their family members |
Management of individuals and early detection/prevention for family members |
Non-psychotic Depression |
CYP450 |
Individuals diagnosed with depression |
Treatment with SSRI drugs |
Ovarian Cancer |
Genomic Tests |
1) General population of
women and;
2)
women at increased risk for ovarian cancer |
1) and 2) Detection and management |
|
F5, F2 |
Individuals with family history or clinical suspicion of thrombophilia |
Prevention and management |