Working Group: Topics




Completed Topics


Test to be Assessed*
Clinical Scenario
Target Population
Intended Use
Gene expression profile
Women diagnosed with
breast cancer
Treatment and
recurrence risk

Multigene panel

General population

Risk prediction or nutritional/lifestyle management

Colorectal Cancer (CRC)


Individuals diagnosed
with CRC

Treatment with irinotecan

Lynch Syndrome/ Hereditary Nonpolyposis Colorectal Cancer (HNPCC)

Mismatch repair gene mutations

Individuals diagnosed with CRC and their family members

Management of individuals and early detection/prevention for family members

Non-psychotic Depression


Individuals diagnosed with depression

Treatment with SSRI drugs

Ovarian Cancer

Genomic Tests

 1) General population of women and;
 2) women at increased risk for ovarian cancer

1) and 2) Detection and management
F5, F2
Individuals with family history or clinical suspicion of thrombophilia
Prevention and management

*variants or mutations in the identified gene or genes


Page last updated: October 4, 2010
Page last reviewed: December 23, 2008
Content Source: EGAPP Team