|
Disorder/Effect
|
Test to be Assessed*
|
Clinical Scenario
|
|
Target Population
|
Intended Use
|
|
|
Gene expression profile
|
Women diagnosed with
breast cancer
|
Treatment and
recurrence risk
|
|
|
Multigene panel
|
General population
|
Risk prediction or nutritional/lifestyle management
|
|
Colorectal Cancer (CRC)
|
UGT1A1
|
Individuals diagnosed
with CRC
|
Treatment with irinotecan
|
|
Lynch Syndrome/ Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
|
Mismatch repair gene mutations
|
Individuals diagnosed with CRC and their family members
|
Management of individuals and early detection/prevention for family members
|
|
Non-psychotic Depression
|
CYP450
|
Individuals diagnosed with depression
|
Treatment with SSRI drugs
|
|
Ovarian Cancer
|
Genomic Tests
|
1) General population of women and;
2) women at increased risk for ovarian cancer
|
1) and 2) Detection and management
|
|
|
F5, F2
|
Individuals with family history or clinical suspicion of thrombophilia
|
Prevention and management
|
